Endocrine Abstracts

Introduction: Insulin resistance occurs in 80% of patients with acromegaly. This report illustrates the case of a female patient with unsatisfactory control of type 2 diabetes and a beneficial effect on glycaemic control after the somatotropic pituitary adenoma surgery.Case report: A 76-year-old female patient with diabetes diagnosed more than twenty years ago was treated with oral hypoglycaemic agents for a long time. In the past ten years she has been ...

Obese subjects have lower risk for osteoporosis than normal weight people. Body mass index over 33 kg/m2 is associated with lowest risk for hip fracture in both sexes.Aim: Investigate overweight influence on bone mineral density of hip bone and lumbar spine in overweight postmenopausal women.Material and methods: Postmenopausal women N=100, without co-morbidity, 48–88 years of age, divided in two groups: grou...

The research included 20 patients of average age 59±8.5 years (ranging from 45 to 75 years of age), of whom there were 8 male patients (40%) and 12 female patients (60%), with average diabetes duration of 4.8±3.16 years. In this group HbA1c levels ranged from 6.6% to 9.4%, while the average BMI level was 30±3.39 kg/m2. Prior to the introduction of gliclazide MR with the daily dosage of 30 mg, all the patients had been treated with metformin with the d...

Metabolic syndrome is risk factor for cardiovascular event. According recommendation of NCEP ATP III, the major component of metabolic syndrome is waist circumference up to 94 cm in male and 80 cm in female, and two of following disturbances: fasting glucose up to 5.6 mmol/l, HDL below 0.9 in male and 1.3 in female, triglycerides up to 1.7 mmol/l and BP up to 135/80 mmHg.We have analyzed the influence of low calorie diet (1200–1500 kcal/day) with in...

Recent studies have suggested that subjects receiving thyroxine replacement therapy are in potentially increased risk of osteoporosis. We set out to measure bone mineral densities by ultrasound bone densitometry (UBMD) in three groups: group A of post-menopausal women (N=25) mean age 65 (±14), group B of women in generative period (N=20) mean age 41(±11), and group C (N=18) male mean age 54, receiving thyroxine replacement therapy during two year...

Ghrelin is able to stimulate HPA axis in both humans and animals. Exaggerated ACTH and cortisol responses to ghrelin have been shown in patients with CD. Here we studied the role of ghrelin alone or in combination with CRH in the diagnosis of CD. In 21 CD patient (18 female, age 49.8±10.2 years, BMI 29.8±0.8 kg/m2, ten macroadenomas 11 microadenomas) we performed: i) ghrelin test (100 μg iv bolus) ii) CRH test (100 μg iv bolus) and iii) ghrelin+C...

Introduction: Gastric bypass surgery in obese patients results in weight loss, changes in gastrointestinal and pancreatic hormones and improvement of insulin sensitivity.Methods: GLP-1, insulin and glucose levels were measured after test meal (Fresubin drink a 200 ml; 200 kcal, 15% protein, 30% fat and 55% carbohydrate) before (day 0) and 5, 90 and 180 days after gastric bypass surgery. Glycaemia (mmol/l; glucose oxidase);GLP-1 (Active 7–36) (pM/l; ...

BMI over 30 kg/m2 is associated with lowest risk for osteoporosis and hip fracture in both sex. Increased body fat mass is followed with greater hip fracture risk, independently of BMI.Aim: Evaluate risk for osteoporosis in postmenopausal female with BMI 25–29.9 kg/m2 and influence of body fat mass on mineral bone density in overweight women.Material and methods: One hundred postmenopausal female, age 48&...

Aim: The aim of our study was to investigate is surgical stress induce alterations in insulin sensitivity in the course of cholecystectomy performed in two differnt procedures: as a open surgery and as laparascopic operation.Material and methods: The homeostasis assessment model (HOMA) was used to determine insulin sensitivity before and in the first, third and seventh day after the operation. Patients were divided int two groups: group A (open cholecyst...

Aim: To calculate mean HbA1c values in patients with type 2 diabetes mellitus in different therapy regiments.Material and methods: Ninety-nine diabetic persons was divided in three groups: group I (n=33) on oral hypoglucemic agents, group II (n=33) on one or two doses of insulin and group III (n=33) on intensive insulin therapy. We have calculated the mean values of HbA1c on the begining and 6 months after start of therapy regiment.<...